Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)
NHGRI seeks applications to study how genomic variations affect genome function and phenotypes using high-throughput methods, as part of the IGVF Consortium.
Funder: National Institutes of Health
Due Dates: December 14, 2026 (Application deadline)
Funding Amounts: $2,000,000 award ceiling; $15,000,000 estimated total funding for 5 awards
Summary: Supports centers using high-throughput methods to characterize how individual genomic variants affect genome function and phenotype.
Key Information: Clinical trials are not allowed, and applications involving foreign subawards or subcontracts will not be considered for funding.
Description
This National Institutes of Health program supports systematic characterization of genomic variation to assess how individual variants affect genome function. Funded centers will perturb variants or elements using one or more high-throughput methods, collect data on effects in DNA, RNA, or protein-coding elements on molecular, cellular, or organismal phenotypes, and develop robust, reproducible, portable data-processing pipelines.
Centers will join the Impact of Genomic Variation on Function (IGVF) Consortium. They will work together to make consortium resources accessible to a wide variety of users and collaborate with other consortium components to coordinate assays, variants, and cell types. Shared analysis strategies are also expected to help meet consortium goals. The program uses the UM1 cooperative agreement mechanism and does not allow clinical trials.
