[Stxbp1 Foundation](https://www.stxbp1disorders.org)

Rolling (Letters of Intent accepted year-round)

Seed Grant: up to $25,000 (1 year) | Trainee Grant: up to $60,000/year (renewable) | Innovation Grant: up to $100,000/year (renewable) | Clinical Grant: up to $150,000 (1 year) | Direct costs only, no indirects

Supports investigator-led research advancing understanding and treatment of STXBP1 disorders, including biology, biomarkers, mechanisms, and therapies.

--- ## Description The STXBP1 Foundation's Grants Program funds investigator-led research projects aimed at deepening the understanding of STXBP1 biology and accelerating the development of transformative therapies for STXBP1-related disorders. Priority research areas include biomarker and clinical endpoint development, mechanisms of neurodegeneration, genotype-phenotype relationships, non-CNS functions of the STXBP1 protein, and drug repurposing opportunities. The program seeks to fill knowledge gaps, encourage innovative research, and ultimately improve outcomes for individuals affected by STXBP1 disorders. --- ## Due Dates - Letters of Intent (LOI) are accepted on a rolling basis throughout the year. - Selected applicants will be invited to submit full proposals after LOI review. --- ## Funding Amount - **Seed Grant:** Up to $25,000 (direct costs, 12 months) - **Trainee Grant:** Up to $60,000 (direct costs, 12 months; may be renewed for a second year) - **Innovation Grant:** Up to $100,000 (direct costs, 12 months; may be renewed for a second year) - **Clinical Grant:** Up to $150,000 (direct costs, 12 months) - **Indirect costs are not supported**; only direct costs can be requested. --- ## Eligibility - Open to research investigators affiliated with academic institutions, hospital systems, non-profit institutions, or other accredited research organizations worldwide (U.S. and international applicants eligible). - Eligible applicants include: - Postdoctoral fellows - Clinical fellows - Researchers - Physicians - Other research professionals with faculty appointments or research positions --- ## Application Process - **Stage 1:** Submit a 1-page Letter of Intent (LOI) as a PDF to [grants@stxbp1disorders.org](mailto:grants@stxbp1disorders.org) including: - Project title - Applicant/PI information (name, position, institution, contact info) - Grant mechanism type - Brief project description (scientific aims, alignment with Foundation goals, approach) - **Stage 2:** Selected applicants will be invited to submit a full proposal using forms provided by the Foundation. - All applications undergo peer review by experts in STXBP1 disorders and related fields. - Evaluation criteria include significance, innovation, feasibility, investigator/environment, and potential impact. --- ## Additional Information - The Foundation does not cover indirect costs. - Renewal for Trainee and Innovation Grants is at the Foundation's discretion. - Reviewer feedback is provided to applicants. - The Foundation may request modifications to the work plan or budget prior to award finalization. --- ## External Links - [STXBP1 Foundation homepage](https://www.stxbp1disorders.org) - [Full Grants Program Guidelines (PDF)](https://static1.squarespace.com/static/5dfbd743194e190a44c01ec8/t/62581f97edef0161f775b7e7/1649942423266/STXBP1+Disorders+Grants+Program.pdf) --- ## Contact Information | Contact | Email | Phone | Address | |--------------------------|-----------------------------------------|---------------|-----------------------------------------| | STXBP1 Foundation Grants | [grants@stxbp1disorders.org](mailto:grants@stxbp1disorders.org) | 317-437-3247 | PO Box 1148, Holly Springs, NC 27540, United States |

Grants Program - Stxbp1 Foundation

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