Funder: Patient-Centered Outcomes Research Institute
Due Dates: January 6, 2027, 5 p.m. ET (LOI) | May 4, 2027, 5 p.m. ET (Application)
Funding Amounts: Up to $12 million in direct costs over five years; up to $60 million available overall
Summary: Supports patient-centered comparative clinical effectiveness research evaluating digital health technologies to improve clinical outcomes and healthcare decisions.
Key Information: The specific digital technology must have evidence of efficacy or widespread use, with product development complete.
Description
The Patient-Centered Outcomes Research Institute (PCORI) supports high-impact comparative clinical effectiveness research addressing evidence gaps in digital health technologies. These include mobile health applications, wearable and implantable devices, remote monitoring tools, technologies integrating patient-generated data into care, and artificial intelligence. Studies should compare approaches that reflect patients’ needs and values and produce meaningful patient-centered clinical outcomes.
Three Special Areas of Emphasis guide the initiative without limiting submissions: enhancing health self-management, incorporating patient-generated data into clinical workflows, and promoting individualized health management. Priorities include accessibility, sustained engagement, actionable and sustainable data integration, and identifying which patients benefit most. Patients and healthcare partners are expected to contribute lived experience and professional expertise throughout the research process.
