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    Forecast for HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)

    NIH will soon offer funding for research to develop non-addictive small molecule and biologic pain treatments, supporting projects from early optimization through Phase I trials as part of the HEAL Initiative.

    OverviewSimilar Grants
    OverviewSimilar Grants

    HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)

    Funding for research developing non-addictive pain treatments through early drug discovery to support the Pain Therapeutics Development Program.

    HHS-NIH11Due Dec 16, 2026$350,000

    HEAL Initiative: Integrative Management of Chronic Pain and Opioid Use Disorder (OUD) for Whole Recovery: Health Systems

    This grant will fund research to develop and implement health system strategies for integrating chronic pain and opioid use disorder care, improving access, collaboration, and sustainability of effective treatments.

    HHS-NIH11Due Jan 26, 2027

    A Holistic Approach to Study Non-Addictive Natural Products for Pain Management

    This grant supports interdisciplinary research to understand how non-addictive natural products manage chronic pain through holistic, multisystem approaches, aiming to develop safe, evidence-based pain relief strategies.

    HHS-NIH11Forecasted May 25, 2027Forecasted

    HEAL Initiative Whole Joint Health Program

    This grant supports phased research to uncover and target multi-tissue mechanisms of joint pain, aiming to develop safe, non-addictive, non-drug interventions to improve outcomes for people with chronic joint pain.

    HHS-NIH11Due Oct 30, 2026· 3d

    HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center

    This grant supports research to improve and integrate care for people with both chronic pain and opioid use disorder, focusing on scalable, sustainable solutions and stakeholder engagement through the BEACON Center.

    HHS-NIH11Due Jan 26, 2027