HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)
Forecasted
This upcoming grant will fund large, multisite clinical trials to test pain management strategies that reduce opioid use and improve outcomes for various pain conditions as part of the HEAL Initiative.
Funder: National Institutes of Health
Due Dates: January 5, 2026 (estimated, forecasted)
Funding Amounts: Not yet specified; large, multisite clinical trials supported; UG3/UH3 mechanism.
Summary: Supports planning and implementation of large-scale clinical trials evaluating interventions to reduce opioid use, improve function, and relieve pain.
Key Information: This is a forecasted opportunity; application details and funding amounts will be released in the official NOFO.
Description
The National Institutes of Health (NIH), led by the National Institute of Neurological Disorders and Stroke (NINDS) and several collaborating institutes, intends to support large, multisite clinical trials through the HEAL Initiative Pain Management Effectiveness Research Network. This opportunity will fund projects that evaluate the efficacy or effectiveness of interventions or management strategies aimed at reducing opioid use, improving functional outcomes, and alleviating pain across acute and chronic pain conditions.
The program seeks to expand the suite of evidence-based therapeutics for pain management, benefiting patients and families affected by pain. The initiative encourages collaborative research involving clinical trials of pharmaceuticals (including repurposed drugs) and devices. This opportunity is announced in advance to allow researchers time to form collaborations and develop robust proposals.
