Funder: National Institutes of Health
Due Dates: November 5, 2026 (Resubmission/revision) | February 5, 2027 (New) | March 5, 2027 (Resubmission/revision) | June 5, 2027 (New) | July 5, 2027 (Resubmission/revision) | October 5, 2027 (New) | November 5, 2027 (Resubmission/revision) | January 7, 2028 (Closing date)
Funding Amounts: No budget cap; requests must reflect project needs; up to 5 years; no cost sharing required
Summary: Supports invasive neural recording and stimulation studies in humans to understand neural circuitry relevant to mental health disorders.
Key Information: Neuroethical considerations are required; animal studies and therapeutic-device intervention-development trials are not responsive.
Description
The National Institute of Mental Health (NIMH), part of NIH, offers this R01 opportunity to address gaps in understanding the neural circuits and dynamics underlying moods, emotions, cognition, and behavior. Projects should ask mental health-relevant questions suited to invasive human recordings and offer high translational potential, without necessarily producing immediate therapies. Stimulation through recording electrodes can support causal tests of circuit function.
Research opportunities include intra-operative recordings during deep brain stimulation surgery, epilepsy-monitoring recordings, and chronic recording/stimulating devices. Participants may have implants for mental health or other clinical indications. Prospective and retrospective data are allowed. The program encourages teams with varied clinical neuroscience expertise and collaborations that increase recruitment.
