HDF Transformative Research Award
HDF Transformative Research Award supports collaborative teams exploring new Huntington's disease mechanisms, tools, and therapeutic approaches to connect fundamental discoveries to disease-modifying therapies.
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Funder: Huntington's Disease Foundation
Due Dates: January 15, 2027 (LOIs open) | February 19, 2027 (LOIs due) | April 1, 2027 (Full proposal invitations) | May 14, 2027 (Full proposals due) | Summer 2027 (Awards announced) | August–September 2027 (Project start)
Funding Amounts: $300,000–$500,000 per award per year for up to two years
Summary: Supports collaborative teams developing new Huntington’s disease mechanisms, tools, and therapeutic approaches with disease-modifying potential.
Key Information: The contact PI must hold an academic appointment with institutional commitment; full proposals are invitation-only.
Description
The Huntington’s Disease Foundation (HDF) Transformative Research Award supports collaborative projects that reveal new Huntington’s disease (HD) mechanisms or create or implement tools and technologies not previously applied to HD research. The goal is to advance fundamental discoveries and conceptually new therapeutic approaches, with a credible path connecting research results to therapies.
Areas of interest include whether modulating somatic repeat instability modifies disease, whether cellular, biochemical, or molecular insights predict disease, and how unexplored therapeutics—including biomarkers—could reach clinical application. Exceptional novelty is central: the program exclusively supports developing and testing new ideas, not incremental advances on published research. Partnerships across disciplines, between academia and industry, and with experts outside the HD field are strongly encouraged.
