Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research PCORI Funding Announcement -- Cycle 1 2027
PCORI's 2027 grant funds research to improve methods in patient-centered comparative clinical effectiveness, focusing on measurement, real-world data, AI/ML, and study design.
Funder: Patient-Centered Outcomes Research Institute
Due Dates: January 6, 2027 (Letter of Intent) | May 4, 2027 (Application)
Funding Amounts: Up to $750,000 direct costs per project (max 3 years); total funds available up to $12 million.
Summary: Supports research to improve methods in patient-centered comparative clinical effectiveness research, focusing on measurement, real-world data, AI/ML, and study design.
Key Information: Letter of Intent required to apply; strong emphasis on patient and stakeholder engagement.
Description
This opportunity from the Patient-Centered Outcomes Research Institute (PCORI) aims to advance the science of patient-centered comparative clinical effectiveness research (CER) by addressing key methodological gaps. The focus is on developing and strengthening methods in four priority areas:
- Patient-centered measurement,
- Use of real-world data in multi-site CER,
- Integration of artificial intelligence (AI) and machine learning (ML), and
- Improvements in study design for patient-centered CER.
Projects funded under this program are expected to enhance the validity, reliability, and applicability of CER, ultimately supporting the generation of high-quality evidence that reflects patient experiences and informs healthcare decision-making. Proposals must demonstrate meaningful engagement with patients and stakeholders throughout the research process.
