Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research PCORI Funding Announcement -- Cycle 1 2027
PCORI’s 2027 grant funds innovative research to improve methods for patient-centered comparative clinical effectiveness studies, focusing on measurement, real-world data, AI, and study design.
Funder: Patient-Centered Outcomes Research Institute
Due Dates: January 6, 2027 (Letter of Intent) | May 4, 2027 (Full application)
Funding Amounts: Up to $750,000 direct costs per project (max 3 years); total available up to $12 million
Summary: Supports research to advance methods in patient-centered comparative clinical effectiveness research, emphasizing measurement, real-world data, AI, and study design.
Key Information: Applicants must address PCORI's Foundational Expectations for Partnerships in Research.
Description
This opportunity from the Patient-Centered Outcomes Research Institute (PCORI) funds projects that develop and improve methods for conducting patient-centered comparative clinical effectiveness research (CER). The focus is on addressing critical methodological gaps that enhance the strength and utility of CER, with Cycle 1 2027 emphasizing:
- Methods for patient-centered measurement, including standardized assessment of burdens, economic outcomes, and contextual factors.
- Methods to optimize use of real-world data in multi-site CER.
- Application and advancement of artificial intelligence (AI) and machine learning in CER.
- Innovations in overall study design for patient-centered CER.
A new priority area—patient-centered measurement—has been introduced, and applicants are expected to engage patients and research partners meaningfully throughout the project.
