The Role of the Innate Immune System in the Pathogenesis of Type 1 Diabetes
Forecasted
NIH funding supports multidisciplinary studies of how innate immune responses and environmental factors contribute to the onset of type 1 diabetes, with the aim of improving risk identification and prevention.
Funder: National Institutes of Health
Due Dates (Anticipated): October 2027 (application due)
Funding Amounts: $15 million in estimated total program funding; 7 awards expected
Summary: Supports research on how the innate immune system contributes to the initiation of type 1 diabetes.
Key Information: The program seeks multidisciplinary expertise in innate immunity and beta-cell biology.
Description
The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), plans to support cooperative agreements studying the innate immune system’s role in the initiation of type 1 diabetes. The initiative uses Special Statutory Funding Program for Type 1 Diabetes Research funds and aligns with the Special Diabetes Program goal of identifying genetic and environmental causes of the disease.
The program seeks to clarify how innate immune components interact with pancreatic tissues and beta cells. It emphasizes multidisciplinary teams and new approach methodologies to define when environmental perturbations activate innate immune pathways and what effects they have. The work may help identify people at elevated risk beyond genetic susceptibility and inform future prevention and treatment strategies.
