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[Alex's Lemonade Stand Foundation](https://www.alexslemonade.org)

October 15, 2026 (Letter of Intent) | March 18, 2027 (Full Application)

Up to $250,000 total over 2 years (max $125,000/year); no renewals, one no-cost extension allowed.

Supports experienced investigators proposing novel, high-impact research into the causes and cures of childhood cancers.

Letter of Intent required; only invited applicants may submit a full proposal.

--- ## Description The Innovation Grants program, offered by Alex's Lemonade Stand Foundation (ALSF), provides significant seed funding to experienced investigators with novel and promising approaches to researching the causes and cures of childhood cancers. The program targets bold, creative projects that may not yet have access to large-scale funding, aiming to accelerate breakthroughs in pediatric oncology and foster the development of new clinical interventions. ALSF prioritizes research with the potential for major scientific or clinical impact and encourages proposals that represent new research directions for established investigators. --- ## Due Dates - Letter of Intent Due: October 15, 2026 (by 8:00 p.m. Eastern) - Full Application Due (by invitation only): March 18, 2027 (by 8:00 p.m. Eastern) --- ## Funding Amount - Total award: Up to $250,000 over two years (maximum $125,000/year) - No renewals; one no-cost extension of up to 12 months may be requested - Indirect costs are not allowed; ALSF adheres to the NIH Salary Cap for PIs --- ## Eligibility - Applicant institutions must be based in the United States or Canada; applicants do not need to be U.S. citizens. - Funds must be awarded to nonprofit institutions or organizations. - PIs and Co-PIs must hold an MD, PhD, or MD/PhD (or equivalent) and be appointed as faculty (or equivalent) at an academic institution. - PIs and Co-PIs must have: - At least one publication as Senior Corresponding Author - A track record of research grant productivity, including at least one NIH R01 or equivalent award (see ALSF R01 equivalency policy) - The proposed project must represent a new research direction, not a continuation of ongoing funded research. - Only one LOI may be submitted per PI or Co-PI per cycle. - At the time of award, researchers may not have active ALSF grants totaling $125,000/year or more (including concurrent Innovation Grants). - Proposals for research using human embryonic/fetal stem cells or non-human primates are not eligible; research with human induced pluripotent stem cells is permissible. - Projects must focus on childhood cancers (not primarily on patients >19 years old). --- ## Application Process ### Step 1: Letter of Intent (LOI) - All applicants must submit a LOI by the deadline. - The LOI must follow the specific content and formatting guidelines outlined in the [2027 Innovation Grant Full Application Guidelines (PDF)](https://www.alexslemonade.org/sites/default/files/images/alsf1/downloads/2027_innovation_grant_guidelines.pdf). - LOIs not conforming to guidelines will be administratively rejected. ### Step 2: Full Application (by invitation only) - Only applicants invited after LOI review may submit a full proposal. - Full proposals must be submitted as a single PDF (max 20 MB) via [Proposal Central](https://proposalcentral.com). - Application sections include project information, budget/justification, biographical sketches, research plan, resource sharing, and supporting documents. - An ORCID iD is required for application submission. ### Additional Requirements - Resource Sharing Plan (using ALSF’s form) is mandatory. - Annual progress reports and a final report are required. - Publications and presentations must acknowledge ALSF funding. --- ## Additional Information - Only one resubmission of a previously reviewed application is permitted, with a required response to prior critique. - Minor carry-over of funds (≤25%) is allowed with justification. - ALSF does not negotiate or modify its grant agreement or IP policy. - For examples of previously funded Innovation Grants, see [funded projects](https://www.alexslemonade.org/where-money-goes/research/program-areas/early-career-research-programs/innovation-award). --- ## External Links - [Program Overview & Guidelines](https://www.alexslemonade.org/grants/program-areas/accelerator-programs) - [2027 Innovation Grant Full Application Guidelines (PDF)](https://www.alexslemonade.org/sites/default/files/images/alsf1/downloads/2027_innovation_grant_guidelines.pdf) - [Proposal Central Application Portal](https://proposalcentral.com) - [Resources for Grant Applicants](https://www.alexslemonade.org/grants/resources-applicants) - [Funded Innovation Projects](https://www.alexslemonade.org/where-money-goes/research/program-areas/early-career-research-programs/innovation-award) --- ## Contact Information | Name / Role | Email | Phone | |------------------------------------|--------------------------------------------|-------------------| | Katy Estes-Smargiassi, Grant Coordinator | K.Esmargiassi@AlexsLemonade.org | 866-333-1213 ext. 143 | | General Grants Inquiries | Grants@AlexsLemonade.org | 610-649-3034 | | Technical/Application Portal Support | pcsupport@altum.com | |79:T6cb,## Grant Eligibility Requirements ### Organization Type - Only organizations may apply: funds must be granted to nonprofit institutions or organizations — individual researchers cannot apply directly. ### Career Stage - PIs and Co-PIs must be appointed as faculty (or equivalent) at an academic institution (i.e., the grant targets established investigators, not trainees). ### Degree Requirements - PIs and Co-PIs must hold an MD, PhD, MD/PhD, or equivalent degree. ### Geographic/Institutional - Applicant institutions must be based in the United States or Canada. ### Prior Funding / Proposal Limits - PIs and Co-PIs must have a track record of research grant productivity, including at least one NIH R01 or equivalent award (per ALSF's R01 equivalency policy). - At the time of award, researchers may not have active ALSF grants totaling $125,000/year or more (including concurrent Innovation Grants). - Only one LOI may be submitted per PI or Co-PI per cycle. - Only one resubmission of a previously reviewed full application is permitted. ### Other Eligibility Requirements - Full applications are by invitation only: applicants must submit a Letter of Intent and may submit a full proposal only if invited after LOI review. - The proposed project must represent a new research direction, not a continuation of the applicant's ongoing funded research. - PIs and Co-PIs must have at least one publication as Senior Corresponding Author. - Proposals must focus on childhood cancers; proposals with a sole/primary focus on patients over age 19 will not be considered. - Research using human embryonic or fetal stem cells, or non-human primates, is not eligible; research with human induced pluripotent stem cells is permissible.7a:T8c2,Funder: Alex's Lemonade Stand Foundation Due Dates: October 15, 2026 (Letter of Intent) | March 18, 2027 (Full Application) Funding Amounts: Up to $250,000 total over 2 years (max $125,000/year); no renewals, one no-cost extension allowed. Summary: Supports experienced investigators proposing novel, high-impact research into the causes and cures of childhood cancers. Key Information: Letter of Intent required; only invited applicants may submit a full proposal. --- ## Description The Innovation Grants program, offered by Alex's Lemonade Stand Foundation (ALSF), provides significant seed funding to experienced investigators with novel and promising approaches to researching the causes and cures of childhood cancers. The program targets bold, creative projects that may not yet have access to large-scale funding, aiming to accelerate breakthroughs in pediatric oncology and foster the development of new clinical interventions. ALSF prioritizes research with the potential for major scientific or clinical impact and encourages proposals that represent new research directions for established investigators. --- --- ## Funding Amount - Total award: Up to $250,000 over two years (maximum $125,000/year) - No renewals; one no-cost extension of up to 12 months may be requested --- ## Eligibility - PIs and Co-PIs must hold an MD, PhD, or MD/PhD (or equivalent) and be appointed as faculty (or equivalent) at an academic institution. - PIs and Co-PIs must have: - At least one publication as Senior Corresponding Author - A track record of research grant productivity, including at least one NIH R01 or equivalent award (see ALSF R01 equivalency policy) - The proposed project must represent a new research direction, not a continuation of ongoing funded research. - Only one LOI may be submitted per PI or Co-PI per cycle. - At the time of award, researchers may not have active ALSF grants totaling $125,000/year or more (including concurrent Innovation Grants). - Proposals for research using human embryonic/fetal stem cells or non-human primates are not eligible; research with human induced pluripotent stem cells is permissible. - Projects must focus on childhood cancers (not primarily on patients >19 years old).55:[["$","script",null,{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"{\"@context\":\"https://schema.org\",\"@graph\":[{\"@type\":\"MonetaryGrant\",\"name\":\"Innovation Grants\",\"description\":\"Alex's Lemonade Stand Foundation's Innovation Grants fund experienced researchers pursuing novel, high-impact studies into the causes and cures of childhood cancers.\",\"url\":\"https://atomgrants.com/grant/innovation-grants-alexs-lemonade-stand-foundation\",\"funder\":{\"@type\":\"Organization\",\"name\":\"Alex's Lemonade Stand Foundation\",\"url\":\"https://atomgrants.com/funder/alex-s-lemonade-stand-foundation\",\"sameAs\":\"https://www.alexslemonade.org\"}},{\"@type\":\"BreadcrumbList\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https://atomgrants.com\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Alex's Lemonade Stand Foundation\",\"item\":\"https://atomgrants.com/funder/alex-s-lemonade-stand-foundation\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Innovation Grants\",\"item\":\"https://atomgrants.com/grant/innovation-grants-alexs-lemonade-stand-foundation\"}]}]}"}}],null,["$","$L77",null,{"grant":{"id":"0a4ea5cb-60f8-43fd-8806-f2ab96f3f54f","created_at":"2026-07-02T09:48:27.09887+00:00","updated_at":"2026-09-05T13:38:48.46423+00:00","title":"Innovation Grants","description":"The Innovation Grants program, funded by Alex's Lemonade Stand Foundation, is designed to fuel high-impact, cutting-edge scientific research focused on uncovering the causes and advancing cures for childhood cancers. 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Innovation Grants

Innovation Grants

Young Investigator Grants

Reach Grants

'A' Award Grants

Bio-Therapeutic Impact Award

R Accelerated Award Grants

Young Investigator Grants

Reach Grants

'A' Award Grants

Bio-Therapeutic Impact Award

R Accelerated Award Grants