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    NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required)

    Funding for early phase clinical trials of natural products, including botanicals and dietary supplements, to assess impact on target engagement and patient outcomes.

    OverviewSimilar Grants
    OverviewSimilar Grants

    NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required)

    This grant funds early phase clinical trials testing natural products like botanicals, probiotics, and dietary supplements with strong scientific backing for further testing.

    HHS-NIH11Due Nov 13, 2026· 18d$350,000

    NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required)

    This grant supports mid-phase clinical trials of promising natural products for determining optimal doses/formulations or patient responses, excluding cancer trials.

    HHS-NIH11Due Nov 13, 2026· 18d

    Early to Definitive Clinical Trials (R61/R33 Clinical Trial Required)

    NIH plans a milestone-driven award supporting planning and early to definitive clinical trials across biomedical and other interventions for up to 7 years; applications are not yet being accepted.

    HHS-NIH11Forecasted Jul 31, 2027Forecasted

    Efficient and Innovative Natural History Studies Addressing Unmet Needs in Rare Diseases (R01 Clinical Trials Optional)

    This grant funds innovative natural history studies to improve understanding and support medical product development for rare diseases with unmet needs.

    HHS-FDA$400,000Forecasted

    Reissue of RFA-FD-22-001 - Efficient and Innovative Natural History Studies Addressing Unmet Needs in Rare Diseases (R01 Clinical Trials Optional)

    This grant funds innovative natural history studies to advance medical product development and address unmet needs in rare diseases by generating high-quality, interpretable data.

    HHS-FDADue Jan 7, 2028$2,400,000