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    National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U01 Clinical Trial Optional)

    Funding available for research on innovative drug and device treatments for mental disorders, substance use, and alcohol use, promoting collaboration between academia and industry through U01 mechanism.

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    Neuroscience Research Grants 2026
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    National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U19 Clinical Trial Optional)

    Funding for collaborative research on new treatments for mental disorders, substance use disorders, and alcohol use disorder, emphasizing novel drugs/devices and industry-academic partnerships.

    HHS-NIH11Due Feb 25, 2027

    Exploratory Clinical Neuroscience Research on Substance Use Disorders (R61/R33 Clinical Trial Optional)

    NIH supports exploratory, phased clinical research on the neurobiological mechanisms of substance use disorders, including relevant circuitry and behavior; clinical trials are optional.

    HHS-NIH11Due Nov 2, 2026· 4d

    First in Human and Early Stage Clinical Trials of Novel Investigational Drugs or Neuromodulatory Device-based Interventions for Psychiatric Disorders (U01 Clinical Trial Required)

    This grant funds early stage trials of new drugs and neuromodulatory devices for psychiatric disorders, aiming to de-risk and attract further funding.

    HHS-NIH11Due Feb 17, 2027$27,000,000

    Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)

    Supports preclinical and clinical research to develop interventions to prevent or treat substance use disorders and overdose, advancing candidates toward regulatory approval or clinical adoption.

    HHS-NIH11Due Feb 22, 2027$15,000,000

    Alzheimer's Drug-Development Program (U01 Clinical Trial Optional)

    Funding for Alzheimer's drug development from pre-clinical to Phase I clinical trials to prevent, slow, or treat AD symptoms, excluding basic research and non-pharmacological interventions.

    HHS-NIH11Due Nov 5, 2026· 7d$1,500,000