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    Seamless Early-Stage Clinical Drug Development (Phase 1 to 2a) for Novel therapeutic Agents for the Spectrum of Alzheimer's Disease (AD) and AD-related Dementias (ADRD) (UG3/UH3 Clinical Trial Required)

    This grant supports combined Phase 1/2a clinical trials testing new drugs (excluding amyloid/tau targets) for Alzheimer's, using a milestone-driven approach.

    OverviewSimilar Grants
    OverviewSimilar Grants

    Alzheimer's Drug-Development Program (U01 Clinical Trial Optional)

    Funding for Alzheimer's drug development from pre-clinical to Phase I clinical trials to prevent, slow, or treat AD symptoms, excluding basic research and non-pharmacological interventions.

    HHS-NIH11Due Nov 5, 2026· 7d$1,500,000

    Alzheimers Drug-Development Program (U01 Clinical Trial Optional)

    This grant supports academic and biotech researchers in developing new drugs to prevent, slow, or treat Alzheimer’s disease through preclinical and early-stage clinical research.

    HHS-NIH11Forecasted Jun 18, 2027Forecasted

    Translational Bioinformatics and Experimental Approaches to Advance Drug Repositioning and Combination Therapy Development for Alzheimers Disease and Related Dementias (R01 Clinical Trial Not Allowed)

    Use mouse models to test existing and investigational drugs for Alzheimer's; focus on drug repositioning and combo therapy development.

    HHS-NIH11Due Nov 6, 2026· 8d$5,000,000

    Drug Development RFP

    Drug Development RFP supports researchers and clinicians developing drugs and devices through IND-enabling studies and early clinical trials to advance treatments for Alzheimer’s disease and related dementias.

    Alzheimers Drug DiscoveryDue Dec 7, 2026$5,000,000

    First in Human and Early Stage Clinical Trials of Novel Investigational Drugs or Neuromodulatory Device-based Interventions for Psychiatric Disorders (U01 Clinical Trial Required)

    This grant funds early stage trials of new drugs and neuromodulatory devices for psychiatric disorders, aiming to de-risk and attract further funding.

    HHS-NIH11Due Feb 17, 2027$27,000,000