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    NSF X-Labs Initiative

    NSF X-Labs Initiative supports interdisciplinary research teams developing breakthrough science and transformative platform technologies to unlock new sectors and strengthen U.S. science and technology leadership.

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    This grant was recently updated

    NSF released the “From Sequence to Function” topic announcement in October 2026 and renamed “Artificial Intelligence for Physical Systems” to “Super Intelligence for Physical Systems.” A From Sequence to Function Q&A is scheduled for November 18, 2026, 2–3 p.m. EST; other webinar resources also changed.

    U.S. National Science Foundation (NSF) X-Labs Initiative

    The NSF X-Labs Initiative funds interdisciplinary teams to develop groundbreaking platform technologies in fields like sensing, imaging, and quantum systems, advancing U.S. science and technology leadership.

    NSF-XLabsDue May 14, 2028$1,500,000,000

    NSF X-Labs Initiative - From Sequence to Function

    NSF X-Labs Initiative - From Sequence to Function supports bioengineering teams developing platform technologies to link protein sequence and structure to predictable or controllable biological function.

    NSF-XLabsDue Feb 8, 2027$1,500,000,000

    NSF X-Labs Initiative – AI for Physical Systems Topic Announcement

    NSF X-Labs Initiative – AI for Physical Systems Topic Announcement supports technology developers advancing early-stage AI platforms to enable intelligent, adaptive, scalable systems in the physical world.

    NSF-XLabsDue Jan 7, 2027

    Small Business Innovation Research / Small Business Technology Transfer Phase I, Phase II, Fast-Track Programs (SBIR/STTR): A Pilot Emphasis on Scientific Instrumentation.

    NSF’s SBIR/STTR pilot funds up to $2M for startups and small businesses developing next-generation scientific instruments and technologies to advance scientific discovery and innovation in the U.S.

    NSFDue Nov 4, 2026· 1d$30,000,000

    NSF National Quantum Virtual Laboratory - Quantum Testbeds

    NSF seeks proposals for Design- and Implementation-phase Quantum Science and Technology Demonstration projects within the National Quantum Virtual Laboratory, building on existing pilot and design projects.

    NSFDue Apr 6, 2027$60,000,000Limited submission