Path to a Cure: Collaborative Research Grant
Path to a Cure: Collaborative Research Grant supports research teams developing CFTR gene repair and replacement delivery technologies to address unmet treatment needs among people with cystic fibrosis.
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Funder: Cystic Fibrosis Foundation
Due Dates: December 15, 2026, at 5 p.m. ET (Full application)
Funding Amounts: Up to $1,000,000 in direct costs annually for up to three years, plus 12% indirect costs
Summary: Supports integrated collaborative research advancing delivery of CFTR gene repair and replacement therapies for cystic fibrosis.
Key Information: Program staff presubmission approval is required at least one month before the deadline to avoid administrative withdrawal.
Description
The Cystic Fibrosis Foundation’s Path to a Cure Collaborative Research Grant supports ambitious, integrated research programs developing new therapies or therapeutic strategies for cystic fibrosis. Its emphasis is on delivering CFTR gene repair and replacement technologies to human epithelia, addressing unmet needs among people whose CFTR variants do not respond to modulators, produce insufficient protein for correction, or prevent protein synthesis.
Programs must bring together related, synergistic projects around a shared theme and objective. Research priorities include cellular targets for nucleotide-based therapies, viral and non-viral delivery vehicles, lung cell types and regions requiring treatment, barriers to genetic therapy delivery, and the effects and durability of genetic manipulation. Collaborations introducing new investigators and technologies to CF research receive highest priority. Multi-institution collaborations are encouraged, but investigators may collaborate within one institution.
