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    Pilot and Feasibility Awards

    Pilot and Feasibility Awards support CF researchers, including new investigators, in testing innovative basic science hypotheses or methods to understand disease mechanisms and inform prevention or treatment.

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    This grant was recently updated

    The RFA now covers Fall 2026, replacing the May 12, 2026 application deadline with December 8, 2026, and moving the earliest project start from November 1, 2026 to May 1, 2027. It also adds a one-application-per-laboratory limit per cycle, excluding training awards, and other eligibility and research-scope details.

    Funder: Cystic Fibrosis Foundation

    Due Dates: December 8, 2026, at 5 p.m. ET (Fall full application)

    Funding Amounts: Up to $50,000 per year, plus 12% indirect costs, for up to two years

    Summary: Supports innovative, hypothesis-driven basic science studies testing new hypotheses or methods relevant to cystic fibrosis.

    Key Information: Only one Pilot and Feasibility Award application is permitted in 2026, in either Spring or Fall.


    Description

    The Cystic Fibrosis Foundation’s Pilot and Feasibility Awards support basic science projects that develop and test new hypotheses or methods, including methods being applied to CF for the first time. The program also supports promising new investigators establishing themselves in CF research. High-risk, high-reward studies are encouraged, with the aim of generating data for subsequent applications to the National Institutes of Health or other funding agencies.

    Proposed work must be hypothesis-driven and innovative, addressing critical questions about CF disease mechanisms or strategies to prevent or treat CF. Preliminary data are not required but will be evaluated if included. The program does not support continued funding, extensions of previous projects, or long-term investigator support. Interventional clinical research and research restoring CFTR function or fixing or replacing the CFTR gene belong under separate funding mechanisms.


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