Invite only: Precision prevention: biological mechanisms of response variation
UK Research and Innovation funds human studies to uncover biological reasons for varied responses to biomedical prevention, aiming to advance precision prevention strategies.
Funder: UK Research and Innovation
Due Dates: November 5, 2026 (Closing date)
Funding Amounts: Up to £5 million (FEC) per project over up to 5 years; MRC funds 80% FEC (max £4 million), 100% for permitted exceptions. Total fund: £15 million.
Summary: Supports human studies to uncover biological reasons for varied responses to biomedical prevention, aiming to refine and personalize precision prevention strategies.
Key Information: Invite only; you must have submitted an EOI and received an invitation to apply.
Description
This Medical Research Council (MRC) opportunity under UK Research and Innovation (UKRI) funds research projects investigating why biomedical prevention interventions elicit different responses across individuals and populations. The focus is on interventional studies in humans that generate mechanistic evidence by testing biomedical experimental interventions or challenges in pre-disease or early disease states. The aim is to identify biological pathways driving response variability, thereby informing more targeted, effective, and equitable precision prevention strategies.
Projects must be hypothesis-driven, involve experimental interventions in humans, and utilize validated biological readouts. The ultimate goal is to inform the timing, targeting, and optimization of prevention interventions, contributing to improved public health outcomes.
