Invite only: Precision prevention: biological mechanisms of response variation
UK Research and Innovation funds human mechanistic research on biological reasons for individual variation in response to biomedical prevention, advancing precision prevention strategies.
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Funder: UK Research and Innovation
Due Dates: November 5, 2026: Full application deadline
Funding Amounts: Up to £5 million (full economic cost) per project over up to 5 years; MRC funds 80% FEC (max £4 million MRC contribution).
Summary: Funds research into the biological mechanisms driving variation in human responses to biomedical prevention interventions, advancing precision prevention strategies.
Key Information: Application is by invitation only after a successful expression of interest (EOI).
Description
This funding opportunity, delivered by the Medical Research Council (MRC) under UK Research and Innovation (UKRI), supports mechanistic research in humans to understand why biomedical prevention interventions yield different outcomes across individuals. The goal is to generate evidence on the biological mechanisms underlying variation in response to preventive interventions, with a focus on the transition from health to early disease. Projects must test mechanistic hypotheses using experimental interventions or challenges in humans, aiming to inform more targeted, effective, and equitable precision prevention strategies.
