Combined inhibition of RANKL/RANK and DYRK1A pathways for T1D therapy supports early-career research on combined pathway inhibition to regenerate and protect pancreatic beta cells in Type 1 diabetes.
LGR4-ECD: A potential therapeutic for type 1 diabetes-related beta cell stress supports Joanna Filipowska’s research on LGR4-ECD to reduce beta-cell stress and preserve insulin secretion in type 1 diabetes.
Project #81: Exploring the Therapeutic Potential of a Novel IRE1 Inhibitor in Type 1 Diabetes supports Luka Suzuki's PAIR2 research to protect beta cells and improve blood-sugar control.
This grant funds research on how mTOR/4E-BP2 signaling controls immune responses to prevent or delay type 1 diabetes, supporting discovery of new molecular targets and therapies.
Project #83: CD318 orchestrates immune regulation and supports beta-cell function in T1D supports Jay Do’s research on CD138 to explore beta-cell protection and reduced inflammation in type 1 diabetes.
Mitigating stress-related cell loss in islet replacement therapy for type 1 diabetes (T1D) supports academic and industry investigators developing ways to reduce transplant cell loss for more durable therapies.