Project #73: Gestation Drives Adaptive Dynamics in Beta Cell Metabolism, Function, and Heterogeneity
This grant supports research into how pregnancy drives adaptive changes in beta cell metabolism and function, aiming to inform therapies for type 1 diabetes.
Funder: Diabetes Research Connection
Due Dates: No specific deadline (applications accepted on a rolling basis)
Funding Amounts: Up to $75,000 per project; typically supports one-year research projects.
Summary: Supports research into how pregnancy stimulates beta cell expansion to inform new therapies for type 1 diabetes.
Description
This funding opportunity, offered by the Diabetes Research Connection (DRC), supports research investigating the mechanisms by which pregnancy naturally expands insulin-producing beta cells in the pancreas. The goal is to uncover the metabolic and genetic pathways involved in this process, with the ultimate aim of applying these insights to restore beta cell populations in individuals with type 1 diabetes (T1D). The project utilizes advanced techniques such as redox microscopy, calcium imaging, and spatial single-cell RNA sequencing in pregnant mice to identify cellular signals and pathways that drive beta cell proliferation during gestation.
