Project #78: Mechanisms and Delivery of FGF19 in Type 1 Diabetes supports Armando Puente’s research on delivering FGF15 to beta cells to test whether it can prevent or delay type 1 diabetes in mice.
Project #83: CD318 orchestrates immune regulation and supports beta-cell function in T1D supports Jay Do’s research on CD138 to explore beta-cell protection and reduced inflammation in type 1 diabetes.
Project #80 supports Dr. Dhanashree Surve’s research on localized combination drug delivery to protect transplanted islet cells from immune rejection and reduce reliance on lifelong immunosuppression.
This grant funds research on how mTOR/4E-BP2 signaling controls immune responses to prevent or delay type 1 diabetes, supporting discovery of new molecular targets and therapies.
Project #81: Exploring the Therapeutic Potential of a Novel IRE1 Inhibitor in Type 1 Diabetes supports Luka Suzuki's PAIR2 research to protect beta cells and improve blood-sugar control.
This grant supports research into how non-glucose nutrients, especially amino acids, boost human beta cell insulin secretion to advance type 1 diabetes therapies.