Project #80 supports Dr. Dhanashree Surve’s research on localized combination drug delivery to protect transplanted islet cells from immune rejection and reduce reliance on lifelong immunosuppression.
Mitigating stress-related cell loss in islet replacement therapy for type 1 diabetes (T1D) supports academic and industry investigators developing ways to reduce transplant cell loss for more durable therapies.
Project #81: Exploring the Therapeutic Potential of a Novel IRE1 Inhibitor in Type 1 Diabetes supports Luka Suzuki's PAIR2 research to protect beta cells and improve blood-sugar control.
Project #86 supports Keiichiro Mine at Boston College in studying whether the gut microbial metabolite isoLCA can reduce inflammatory immune-cell activation to help prevent type 1 diabetes.
Project #76 supports Vira Kravets at UC San Diego in studying alpha cell dysfunction and immune targeting as possible triggers of type 1 diabetes, potentially informing prevention and treatment.
This grant funds research using optogenetics to mature stem cell-derived beta cells for improved type 1 diabetes therapy, supported by the Diabetes Research Connection.