This grant supports research on how BNIP3-mediated mitophagy affects beta cell identity and immune response in type 1 diabetes, aiming to uncover new therapeutic approaches.
This grant funds research on how mTOR/4E-BP2 signaling controls immune responses to prevent or delay type 1 diabetes, supporting discovery of new molecular targets and therapies.
Project #83: CD318 orchestrates immune regulation and supports beta-cell function in T1D supports Jay Do’s research on CD138 to explore beta-cell protection and reduced inflammation in type 1 diabetes.
Project #86 supports Keiichiro Mine at Boston College in studying whether the gut microbial metabolite isoLCA can reduce inflammatory immune-cell activation to help prevent type 1 diabetes.
This grant supports research into how pregnancy drives adaptive changes in beta cell metabolism and function, aiming to inform therapies for type 1 diabetes.
Project #81: Exploring the Therapeutic Potential of a Novel IRE1 Inhibitor in Type 1 Diabetes supports Luka Suzuki's PAIR2 research to protect beta cells and improve blood-sugar control.