Project #86 supports Keiichiro Mine at Boston College in studying whether the gut microbial metabolite isoLCA can reduce inflammatory immune-cell activation to help prevent type 1 diabetes.
Project #83: CD318 orchestrates immune regulation and supports beta-cell function in T1D supports Jay Do’s research on CD138 to explore beta-cell protection and reduced inflammation in type 1 diabetes.
This grant supports research on how BNIP3-mediated mitophagy affects beta cell identity and immune response in type 1 diabetes, aiming to uncover new therapeutic approaches.
Project #80 supports Dr. Dhanashree Surve’s research on localized combination drug delivery to protect transplanted islet cells from immune rejection and reduce reliance on lifelong immunosuppression.
Project #76 supports Vira Kravets at UC San Diego in studying alpha cell dysfunction and immune targeting as possible triggers of type 1 diabetes, potentially informing prevention and treatment.
Project #59: Determine the role of viral infections and viral-insulin carrying viruses in T1D pathogenesis supports Boston College researchers studying viruses in T1D to inform prevention and treatment.