[Breakthrough T1D](https://www.breakthrought1d.org)

November 6, 2025 (LOI – Round 1) | May 7, 2026 (LOI – Round 2)

No explicit maximum; typical Strategic Research Agreements are milestone-driven, duration and budget negotiated per project; indirect costs capped at 10%.

Semi-annual LOI call for innovative project concepts in type 1 diabetes research, with selected LOIs invited to full Strategic Research Agreement proposals.

--- ## Description Breakthrough T1D’s Project Concepts mechanism is a semi-annual opportunity for researchers to submit Letters of Intent (LOIs) for Strategic Research Agreements (SRAs) that align with the foundation’s evolving Research Strategy in type 1 diabetes (T1D). The goal is to capture and advance innovative project ideas that address key priorities in the prevention, treatment, and cure of T1D. LOIs are reviewed for scientific merit, strategic alignment, and potential impact. Selected concepts may be invited to submit full SRA proposals, which undergo further scientific review. All awarded projects are governed by Breakthrough T1D’s standard grant terms and conditions. --- ## Due Dates - **November 6, 2025:** Letter of Intent (LOI) deadline — Round 1 - **May 7, 2026:** Letter of Intent (LOI) deadline — Round 2 Applicants will be notified of LOI outcomes approximately 6 weeks after each deadline. Invited full proposals will be given specific timelines by Breakthrough T1D. --- ## Funding Amount - **Award Size:** No explicit maximum stated for Project Concepts; budgets are determined per project based on scope and negotiated during the full proposal phase. - **Typical Structure:** Strategic Research Agreements are milestone-driven; funding and duration are tailored to the project. - **Indirect Costs:** Capped at 10% of direct costs (excluding equipment, consultants, and subcontract costs). - **Note:** For-profit organizations may be eligible under special circumstances (see Industry Discovery & Development Partnerships), with additional requirements. --- ## Eligibility - **Institutions:** Domestic and foreign non-profit organizations, public and private universities, colleges, hospitals, laboratories, units of state and local governments, and eligible agencies of the federal government. - **Applicants:** Must hold an MD, DMD, DVM, DO, PhD, or equivalent and have a faculty position or equivalent at a research institution. - **For-profit entities:** Ordinarily not eligible except through the Industry Discovery & Development Partnership (IDDP) mechanism, which requires company matching funds and prior discussion with Breakthrough T1D. - **All proposals:** Must be relevant to type 1 diabetes and align with Breakthrough T1D’s [Research Strategy](https://www.breakthrought1d.org/explore-research/research-strategy/). --- ## Application Process 1. **Review Guidelines:** Carefully read the [Breakthrough T1D Grant Handbook](https://www.breakthrought1d.org/granthandbook/) for eligibility, terms, and SRA requirements. 2. **Prepare LOI:** Draft a concise LOI describing your project concept, following any structure or page limits noted in the Handbook or the [RMS360](https://breakthrought1d.smartsimple.us/) portal. 3. **Submit LOI:** Upload your LOI via the [RMS360 grant portal](https://breakthrought1d.smartsimple.us/) by the relevant deadline. 4. **Review:** LOIs are evaluated for strategic alignment, scientific merit, and potential impact. 5. **Invitation:** If selected, you will be invited to submit a full SRA proposal with additional instructions and timelines. 6. **Full Proposal:** Submit a detailed application (by invitation only) for further review and potential funding. --- ## Additional Information - **Strategic Focus:** Projects must clearly align with Breakthrough T1D’s Research Strategy and address critical gaps or opportunities in T1D prevention, treatment, or cure. - **Reporting:** Funded projects require regular milestone and progress reporting. - **Terms:** All awards are governed by Breakthrough T1D’s general grant terms and conditions. - **Human Subjects/Animal Research:** Compliance with NIH and HHS regulations is required for research involving humans or animals. --- ## External Links - [Breakthrough T1D Funding Opportunities](https://www.breakthrought1d.org/explore-research/funding-opportunities/) - [Breakthrough T1D Grant Handbook](https://www.breakthrought1d.org/granthandbook/) - [Apply via RMS360 Portal](https://breakthrought1d.smartsimple.us/) - [Breakthrough T1D Research Strategy](https://www.breakthrought1d.org/explore-research/research-strategy/) - [Privacy Policy](https://www.breakthrought1d.org/privacy/) --- ## Contact Information | Purpose | Contact Name | Email | |------------------------|-----------------------|----------------------------------------| | Strategic/Scientific | See Grant Handbook or RMS360 | [Contact Form](https://www.breakthrought1d.org/contact-us/) | | General Inquiries | Breakthrough T1D | [Contact Form](https://www.breakthrought1d.org/contact-us/) | For specific questions about eligibility, alignment, or the submission process, use the contact information provided in the [Grant Handbook](https://www.breakthrought1d.org/granthandbook/) or reach out through the [Breakthrough T1D contact page](https://www.breakthrought1d.org/contact-us/).

Project Concepts (Strategic Research Agreement Letters of Intent)

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