[Breakthrough T1D](https://www.breakthrought1d.org)

November 6, 2025 (Round 1 LOI) | May 7, 2026 (Round 2 LOI)

Budget and duration are negotiated after LOI approval; typical Strategic Research Agreements range up to $750,000–$1,500,000 over 2–3 years, but amounts are determined case by case.

Semi-annual mechanism for concept-stage research proposals focused on advancing understanding, prevention, or treatment of type 1 diabetes (T1D).

--- ## Description Breakthrough T1D’s Project Concepts mechanism invites Letters of Intent (LOIs) for innovative, concept-stage research and translational projects that align with the foundation’s current research strategy to cure, prevent, and treat type 1 diabetes (T1D) and its complications. This semi-annual call serves as the entry point for Strategic Research Agreements (SRAs), enabling investigators to propose new directions that could be developed into full-scale research partnerships with Breakthrough T1D. Submitted concepts are reviewed for fit with strategic priorities and anticipated impact, and selected applicants may be invited to submit a full proposal for funding consideration. --- ## Due Dates - November 6, 2025: Project Concepts – Strategic Research Agreement Letter of Intent deadline (Round 1 LOI) - May 7, 2026: Project Concepts – Strategic Research Agreement Letter of Intent deadline (Round 2 LOI) Applicants will be notified of outcomes for Round 1 by December 18, 2025, and for Round 2 by June 18, 2026. --- ## Funding Amount - Funding and project duration are determined through negotiation after successful LOI review and invitation to submit a full proposal. - Typical Strategic Research Agreements (SRAs) fall in the range of $750,000–$1,500,000 total costs over 2–3 years, but actual budgets may vary depending on project scope and justification. - Indirect costs for nonprofit institutions are capped at 10% of direct costs. - For-profit entities may apply under the Industry Discovery & Development Partnership (IDDP) mechanism, with additional requirements and no indirect costs. --- ## Eligibility - Open to domestic and foreign nonprofit organizations (universities, colleges, hospitals, laboratories, government units), as well as eligible for-profit entities (with specific partnership requirements). - Principal Investigators must hold an M.D., D.O., D.M.D., D.V.M., Ph.D., or equivalent and have a faculty (or equivalent) appointment at a research institution. - For-profit applicants or industry-academic collaborations are eligible but subject to additional information requests if invited to submit a full proposal. - Breakthrough T1D encourages diversity and welcomes proposals from all qualified individuals. --- ## Application Process 1. **Review Strategic Priorities:** Align your concept with Breakthrough T1D’s [Research Strategy](https://www.breakthrought1d.org/explore-research/research-strategy/). 2. **Prepare LOI:** Submit a concise, clearly articulated Letter of Intent (typically 2 pages) describing the project’s aims, innovation, alignment with T1D priorities, and potential impact. 3. **Submit via RMS360:** Register and submit your LOI through the [RMS360 platform](https://breakthrought1d.smartsimple.us/) by the relevant deadline. 4. **Review:** LOIs are reviewed for fit and impact. Selected applicants are invited to develop a full proposal, with detailed instructions provided at that stage. 5. **Full Proposal (by invitation only):** Invited applicants submit a full application using RMS360 templates and follow-up instructions. 6. **Award Negotiation:** Funding amounts, durations, and terms are finalized through negotiation following proposal review. --- ## Additional Information - All research must be relevant to T1D and adhere to Breakthrough T1D’s ethical, regulatory, and reporting standards (see [Grant Handbook](https://www.breakthrought1d.org/granthandbook/)). - Human subject research must comply with U.S. Department of Health and Human Services (45 CFR 46) guidelines. - Applications must be submitted in English via RMS360. - Only LOIs submitted by the deadline are eligible for review; late or incomplete submissions will not be considered. --- ## External Links - [Breakthrough T1D Funding Opportunities Overview](https://www.breakthrought1d.org/explore-research/funding-opportunities/#project-concepts) - [Breakthrough T1D Research Strategy](https://www.breakthrought1d.org/explore-research/research-strategy/) - [Grant Handbook](https://www.breakthrought1d.org/granthandbook/) - [RMS360 Application Portal](https://breakthrought1d.smartsimple.us/) - [Privacy Policy](https://www.breakthrought1d.org/privacy/) --- ## Contact Information | Topic | Contact Name | Email | |---------------------------|---------------------|----------------------------------------------| | Scientific Inquiries | Jonathan Rosen, PhD | jrosen@breakthroughT1D.org | | Administrative Inquiries | Sanjukta Mukerjee | smukerjee@breakthrought1d.org | | General Contact | - | [Contact Form](https://www.breakthrought1d.org/contact-us/) | ---

Project Concepts – Strategic Research Agreement Letters of Intent

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