Somatic Mosaicism across Human Tissues (SMaHT) Program: Genome Characterization Centers (UM1 Clinical Trial Not Allowed)
Forecasted
This grant funds centers to study how somatic mutations affect healthy and disease-related human tissues, advancing understanding of their role in biology and disease.
Funder: National Institutes of Health
Due Dates (Anticipated): July 2027 (projected)
Funding Amounts: Expected number of awards: 1; award size not specified; multi-year cooperative agreement.
Summary: Supports research centers to characterize the functional consequences of somatic mutations in human tissues as part of the SMaHT Network.
Key Information: This is a forecasted opportunity; details and deadlines are subject to change.
Description
The Somatic Mosaicism across Human Tissues (SMaHT) Program is an NIH initiative aimed at advancing the understanding of biological processes and disease mechanisms mediated by somatic mutations in human tissues. The Stage 2 Genome Characterization Centers (GCCs) will build on previous work, focusing on determining the functional consequences of somatic mutations in both healthy and clinically relevant tissue samples. This work is intended to support the SMaHT Network’s broader goal of characterizing somatic mosaicism and its implications for human biology and disease.
