Somatic Mosaicism across Human Tissues SMaHT Program: Experimental and Computational Technology Development (RM1 Clinical Trial Not Allowed)
Forecasted
This grant supports developing and sharing new experimental and computational technologies to detect and interpret somatic mutations in human tissues as part of the SMaHT program.
Funder: National Institutes of Health
Due Dates (Anticipated): July 2027 (projected)
Funding Amounts: Award size not yet specified; typically supports multidisciplinary technology development for 3–5 years.
Summary: Supports development and validation of experimental and computational technologies for somatic mutation detection and interpretation across human tissues.
Description
This funding opportunity, part of the Somatic Mosaicism across Human Tissues (SMaHT) Program, aims to advance the development, optimization, validation, benchmarking, and dissemination of rigorous, cost-effective technologies for detecting and functionally interpreting somatic mutations in human tissues. The initiative supports multidisciplinary teams working on both experimental and computational technology development. Awardees will be expected to collaborate within the SMaHT Stage 2 network to integrate validated technologies into production workflows, pipelines, data releases, and community resources, ultimately enhancing understanding of somatic mutations in health and disease.
