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    LeverAging StraTegies to Maximize ImpLementation and Effectiveness for HIV (LAST MILE)

    Forecasted

    This program supports collaborative, real-world trials that test how to implement effective HIV prevention and treatment across populations and care settings.

    Funder: National Institutes of Health

    Due Dates (Anticipated): October 2027 (application due)

    Funding Amounts: 10 awards expected; award amounts are not listed

    Summary: Supports collaborative HIV effectiveness trials that incorporate implementation in real-world settings.

    Key Information: Proposed work must address HIV prevention or treatment, including associated coinfections or comorbidities.


    Description

    The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, plans to support collaborations through the LAST MILE program. The program seeks effectiveness trials that incorporate implementation in real-world settings, bridging findings from traditional clinical trials to their use in care. Examples include combined efficacy-effectiveness trials, pragmatic trials, and hybrid effectiveness-implementation studies.

    Projects may focus on HIV prevention or treatment and associated coinfections and comorbidities, across points of care and age groups. The program aims to advance cross-cutting HIV research in clinical, behavioral and social sciences, epidemiology, and implementation science.


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