UKRI Translation: MRC Proof of Concept: stage one
Funds academically-led translational research to develop and test novel therapeutics, devices, diagnostics, or interventions from prototype through early-phase clinical studies for significant health needs.
Funder: UK Research and Innovation
Due Dates: November 18, 2026 (Stage One) | March 3, 2027 (Stage Two, by invitation) | July 7, 2027 (Stage Two, deferred)
Funding Amounts: No set funding or duration limit; typical awards fund 80% of full economic costs (FEC) for UK applicants, 100% of permitted exceptions, and up to 30% of total costs for international partners.
Summary: Supports academically-led translational projects developing novel therapeutics, devices, diagnostics, or interventions to address significant health needs, from prototype through early-phase clinical studies.
Key Information: Applicants may submit only one application as project lead per round and must be based at an eligible UK research organisation.
Description
This opportunity funds translational research projects led by academic researchers to develop and test innovative therapeutics, medical devices, diagnostics, and other health interventions. The scheme is designed to move concepts from prototype or pre-clinical stages through to early-phase (up to phase 2a) clinical studies, with the aim of de-risking further development and enabling onward investment. Projects may address any significant health need and can also include the development of research tools that accelerate intervention development. The emphasis is on robust planning, innovation management, and responsible research practices.
