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    Exploratory Clinical Neuroscience Research on Substance Use Disorders (R61/R33 Clinical Trial Optional)

    NIH supports exploratory, phased clinical research on the neurobiological mechanisms of substance use disorders, including relevant circuitry and behavior; clinical trials are optional.

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    Neuroscience Research Grants 2026
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    This grant was recently updated

    This grant has transitioned from forecasted to posted and is now accepting applications.

    Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)

    Supports preclinical and clinical research to develop interventions to prevent or treat substance use disorders and overdose, advancing candidates toward regulatory approval or clinical adoption.

    HHS-NIH11Due Feb 22, 2027$15,000,000

    Accelerating the Pace of Substance Use Research Using Existing Data (R21 Clinical Trial Not Allowed)

    This grant funds research on drug use behaviors, prevention, and health services by analyzing existing social science, behavioral, and neuroimaging data.

    HHS-NIH11Due Nov 3, 2026· 5d

    National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U01 Clinical Trial Optional)

    Funding available for research on innovative drug and device treatments for mental disorders, substance use, and alcohol use, promoting collaboration between academia and industry through U01 mechanism.

    HHS-NIH11Due Feb 25, 2027

    Prevention and Intervention Approaches for Fetal Alcohol Spectrum Disorders (R61/R33 Clinical Trial Optional)

    This grant supports research on preventing and treating fetal alcohol spectrum disorders (FASD) through a phased approach, with a focus on clinical trials.

    HHS-NIH11Due Nov 17, 2026· 19d$1,850,000

    Accelerating the Pace of Substance Use Research Using Existing Data (R01 Clinical Trial Not Allowed)

    Use existing data to analyze drug use behaviors, prevention strategies, and service utilization, aiming to advance substance use research.

    HHS-NIH11Due Nov 3, 2026· 5d