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    Neural Ensembles & Used Substances (NExUS) Collaboratory: Building a Multimodal Inventory of Cell Ensembles Encoding the Effects of Addictive Substances (U01 Clinical Trial Not Allowed)

    Supports collaborative research to map neural ensembles responding to addictive substances and build a multimodal database linking their activity to substance use behaviors; clinical trials are not allowed.

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    Neuroscience Research Grants 2026
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    NIDA Animal Genomics Program (U01 Clinical Trial Not Allowed)

    The NIDA Animal Genomics Program aims to identify genetic variants influencing addictive behaviors, SUD stages, associated behaviors, and comorbidities through genomics approaches.

    HHS-NIH11Due Feb 11, 2027

    Exploratory Clinical Neuroscience Research on Substance Use Disorders (R61/R33 Clinical Trial Optional)

    NIH supports exploratory, phased clinical research on the neurobiological mechanisms of substance use disorders, including relevant circuitry and behavior; clinical trials are optional.

    HHS-NIH11Due Feb 19, 2027

    Forecast to Publish a Funding Opportunity Announcement for Copy of Integrative Neuroscience Initiative on Alcoholism (INIA) Consortia Research Resource (U24) (Clinical Trial Optional)

    NIAAA plans to fund two research groups studying how brain and body dysregulation leads to excessive drinking and AUD, using advanced tools and collaborative approaches.

    HHS-NIH11Forecasted

    NIDA Avenir Program: Fundamental Mechanistic Research in Addiction Science

    This grant supports early stage investigators proposing innovative, high-risk research on the biological and behavioral mechanisms underlying substance use disorders.

    HHS-NIH11Forecasted May 26, 2027$375,000Forecasted

    Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)

    NIH supports discovery of in vivo chemical probes for novel brain targets, with applicants expected to have validated starting compounds and bioassays; clinical trials are not allowed.

    HHS-NIH11Due Feb 5, 2027