Project #60: GPER, inflammation and diabetic kidney disease
Diabetes Research Connection funds research on how GPER affects inflammation and kidney disease in type 1 diabetes, aiming to uncover sex-specific mechanisms and new treatment targets.
Funder: Diabetes Research Connection
Due Dates: Rolling
Funding Amounts: Up to $75,000 per project; typically supports 1-year pilot or early-stage research.
Summary: Supports early-career researchers investigating the role of GPER in diabetic kidney disease, emphasizing sex-specific mechanisms and new therapeutic targets.
Description
This opportunity, funded by the Diabetes Research Connection (DRC), supports innovative, early-stage research focused on understanding the role of the G protein-coupled estrogen receptor (GPER) in the development and progression of kidney disease during type 1 diabetes. The project aims to uncover sex-specific mechanisms by which GPER may influence kidney damage and inflammation, using mouse models to determine whether this receptor protects against or exacerbates diabetic kidney injury. The overarching goal is to reveal new therapeutic targets to halt or slow diabetic kidney disease, a major complication affecting a significant proportion of individuals with type 1 diabetes.
