Project #60: GPER, inflammation and diabetic kidney disease supports Carmen De Miguel’s research on GPER in type 1 diabetes to identify therapeutic targets that could stop or delay kidney damage.
This grant funds research exploring how the cGAS-STING pathway causes podocyte injury in type 1 diabetes, aiming to identify new treatment targets for diabetic kidney disease.
Project #81: Exploring the Therapeutic Potential of a Novel IRE1 Inhibitor in Type 1 Diabetes supports Luka Suzuki's PAIR2 research to protect beta cells and improve blood-sugar control.
Combined inhibition of RANKL/RANK and DYRK1A pathways for T1D therapy supports early-career research on combined pathway inhibition to regenerate and protect pancreatic beta cells in Type 1 diabetes.
LGR4-ECD: A potential therapeutic for type 1 diabetes-related beta cell stress supports Joanna Filipowska’s research on LGR4-ECD to reduce beta-cell stress and preserve insulin secretion in type 1 diabetes.
Project #78: Mechanisms and Delivery of FGF19 in Type 1 Diabetes supports Armando Puente’s research on delivering FGF15 to beta cells to test whether it can prevent or delay type 1 diabetes in mice.