Direct reprogramming pancreatic ductal cells into insulin-producing cells by controlling the epigenome using AI-designed mini-protein EpiBinder funds Shiri Levy’s research to restore insulin production in type 1 diabetes.
Project #81: Exploring the Therapeutic Potential of a Novel IRE1 Inhibitor in Type 1 Diabetes supports Luka Suzuki's PAIR2 research to protect beta cells and improve blood-sugar control.
Project #80 supports Dr. Dhanashree Surve’s research on localized combination drug delivery to protect transplanted islet cells from immune rejection and reduce reliance on lifelong immunosuppression.
Mitigating stress-related cell loss in islet replacement therapy for type 1 diabetes (T1D) supports academic and industry investigators developing ways to reduce transplant cell loss for more durable therapies.
This grant funds research using optogenetics to mature stem cell-derived beta cells for improved type 1 diabetes therapy, supported by the Diabetes Research Connection.
This grant funds research on how mTOR/4E-BP2 signaling controls immune responses to prevent or delay type 1 diabetes, supporting discovery of new molecular targets and therapies.