Project #74: The cGAS-STING pathway mediates podocyte injury in type I diabetes
This grant funds research exploring how the cGAS-STING pathway causes podocyte injury in type 1 diabetes, aiming to identify new treatment targets for diabetic kidney disease.
Funder: Diabetes Research Connection
Due Dates (Anticipated): May 2027 (projected)
Funding Amounts: Up to $75,000 per project; typically 1-year duration.
Summary: Supports research on the cGAS-STING pathway’s role in kidney cell injury in type 1 diabetes to identify new treatment strategies for diabetic kidney disease.
Key Information: For early-career scientists; funding is donor-driven and peer-reviewed.
Description
This opportunity from the Diabetes Research Connection funds innovative research on the mechanisms underlying diabetic kidney disease in type 1 diabetes (T1D), specifically focusing on the cGAS-STING pathway. The project aims to determine whether persistent activation of the STING molecule in kidney cells leads to inflammation and cell damage, ultimately contributing to diabetic kidney disease. Using laboratory models and single cell RNA sequencing, the research seeks to clarify how STING activation correlates with disease progression and to uncover potential therapeutic targets for preventing or treating kidney complications in T1D.
