This grant funds research exploring how the cGAS-STING pathway causes podocyte injury in type 1 diabetes, aiming to identify new treatment targets for diabetic kidney disease.
This grant funds research on how mTOR/4E-BP2 signaling controls immune responses to prevent or delay type 1 diabetes, supporting discovery of new molecular targets and therapies.
Project #60: GPER, inflammation and diabetic kidney disease supports Carmen De Miguel’s research on GPER in type 1 diabetes to identify therapeutic targets that could stop or delay kidney damage.
Project #81: Exploring the Therapeutic Potential of a Novel IRE1 Inhibitor in Type 1 Diabetes supports Luka Suzuki's PAIR2 research to protect beta cells and improve blood-sugar control.
This grant supports research on how BNIP3-mediated mitophagy affects beta cell identity and immune response in type 1 diabetes, aiming to uncover new therapeutic approaches.
Project #86 supports Keiichiro Mine at Boston College in studying whether the gut microbial metabolite isoLCA can reduce inflammatory immune-cell activation to help prevent type 1 diabetes.