Project #75: Investigating the Role of KLF4 in Maintenance of Alpha Cell Identity
This Diabetes Research Connection grant supports research into how KLF4 controls pancreatic alpha cell identity and function in type 1 diabetes using advanced cellular models.
Funder: Diabetes Research Connection
Due Dates (Anticipated): May 2027
Funding Amounts: Up to $75,000 per project; typically supports 1-year research projects.
Summary: Supports research on how KLF4 regulates alpha cell identity and function in type 1 diabetes to inform new therapeutic strategies.
Description
This grant opportunity, offered by the Diabetes Research Connection (DRC), supports innovative research focused on the molecular mechanisms by which the DNA-binding protein KLF4 influences pancreatic alpha cell identity and function in the context of type 1 diabetes (T1D). Led by Dr. Eric Januszkiewicz, the project aims to use advanced T1D models and human stem cell-derived islet cells to characterize how KLF4 regulates gene expression in alpha cells. The findings may reveal new insights into T1D disease progression and inform future therapeutic approaches targeting both alpha and beta cell dysfunction.
