This grant supports research into how KLF4 regulates pancreatic alpha cell identity, aiming to reveal new insights into type 1 diabetes mechanisms.
Project #76 supports Vira Kravets at UC San Diego in studying alpha cell dysfunction and immune targeting as possible triggers of type 1 diabetes, potentially informing prevention and treatment.
This grant funds research on how mTOR/4E-BP2 signaling controls immune responses to prevent or delay type 1 diabetes, supporting discovery of new molecular targets and therapies.
Project #86 supports Keiichiro Mine at Boston College in studying whether the gut microbial metabolite isoLCA can reduce inflammatory immune-cell activation to help prevent type 1 diabetes.
LGR4-ECD: A potential therapeutic for type 1 diabetes-related beta cell stress supports Joanna Filipowska’s research on LGR4-ECD to reduce beta-cell stress and preserve insulin secretion in type 1 diabetes.
This grant supports research on how BNIP3-mediated mitophagy affects beta cell identity and immune response in type 1 diabetes, aiming to uncover new therapeutic approaches.