Project #77: Protection Against Type 1 Diabetes Development by mTOR/4E-BP2 Signaling
Forecasted
This grant funds research on how mTOR/4E-BP2 signaling controls immune responses to prevent or delay type 1 diabetes, supporting discovery of new molecular targets and therapies.
Funder: Diabetes Research Connection
Due Dates (Anticipated): May 2027 (Full application deadline, projected)
Funding Amounts: Up to $75,000 per project; typical duration is 1 year.
Summary: Supports early-career research into mTOR/4E-BP2 signaling and immune regulation to prevent or slow the onset of type 1 diabetes.
Key Information: Forecasted opportunity—dates and details subject to change; confirm on the program page before applying.
Description
This grant supports innovative, early-career research focused on the prevention and management of type 1 diabetes (T1D), specifically through investigation of mTOR/4E-BP2 signaling pathways and their role in immune cell regulation. The current project, led by Dr. Valentia Pita Grisanti at the University of Miami, aims to understand how the absence of the protein 4E-BP2 affects the balance between aggressive and regulatory immune cells in the pancreas. Using single cell RNA sequencing, the research seeks to identify molecular pathways, biomarkers, and therapeutic targets that could prevent immune-mediated destruction of insulin-producing beta cells, with the long-term goal of developing new strategies to halt or slow T1D onset.
