This grant funds research on how mTOR/4E-BP2 signaling controls immune responses to prevent or delay type 1 diabetes, supporting discovery of new molecular targets and therapies.
This grant supports research on how BNIP3-mediated mitophagy affects beta cell identity and immune response in type 1 diabetes, aiming to uncover new therapeutic approaches.
Project #81: Exploring the Therapeutic Potential of a Novel IRE1 Inhibitor in Type 1 Diabetes supports Luka Suzuki's PAIR2 research to protect beta cells and improve blood-sugar control.
Project #83: CD318 orchestrates immune regulation and supports beta-cell function in T1D supports Jay Do’s research on CD138 to explore beta-cell protection and reduced inflammation in type 1 diabetes.
Project #76 supports Vira Kravets at UC San Diego in studying alpha cell dysfunction and immune targeting as possible triggers of type 1 diabetes, potentially informing prevention and treatment.
This grant funds research using optogenetics to mature stem cell-derived beta cells for improved type 1 diabetes therapy, supported by the Diabetes Research Connection.