Project #81: Exploring the Therapeutic Potential of a Novel IRE1 Inhibitor in Type 1 Diabetes
Project #81 funds research on a novel IRE1 inhibitor, PAIR2, to protect insulin-producing beta cells in Type 1 Diabetes, supported by Diabetes Research Connection.
Funder: Diabetes Research Connection
Due Dates: Rolling (submit anytime)
Funding Amounts: Up to $75,000 per project; typically for early-stage, innovative research.
Summary: Supports research developing and testing a novel IRE1 inhibitor (PAIR2) to protect insulin-producing beta cells in Type 1 Diabetes.
Key Information: Focused on early-career scientists and pilot/innovative T1D research.
Description
This opportunity, offered by the Diabetes Research Connection (DRC), funds innovative research into Type 1 Diabetes (T1D), with this specific project focused on exploring the therapeutic potential of a novel IRE1 inhibitor (PAIR2). The research aims to reduce endoplasmic reticulum (ER) stress in insulin-producing beta cells, a key factor in their dysfunction and loss during T1D. The project will further test PAIR2 in both diabetic mice and human islet-transplanted models, aiming to reveal its potential for protecting human beta cells and paving the way for new therapies that maintain endogenous insulin production.
