Project #81: Exploring the Therapeutic Potential of a Novel IRE1 Inhibitor in Type 1 Diabetes supports Luka Suzuki's PAIR2 research to protect beta cells and improve blood-sugar control.
This grant funds research on how mTOR/4E-BP2 signaling controls immune responses to prevent or delay type 1 diabetes, supporting discovery of new molecular targets and therapies.
This grant supports research on how BNIP3-mediated mitophagy affects beta cell identity and immune response in type 1 diabetes, aiming to uncover new therapeutic approaches.
Project #80 supports Dr. Dhanashree Surve’s research on localized combination drug delivery to protect transplanted islet cells from immune rejection and reduce reliance on lifelong immunosuppression.
Direct reprogramming pancreatic ductal cells into insulin-producing cells by controlling the epigenome using AI-designed mini-protein EpiBinder funds Shiri Levy’s research to restore insulin production in type 1 diabetes.
Combined inhibition of RANKL/RANK and DYRK1A pathways for T1D therapy supports early-career research on combined pathway inhibition to regenerate and protect pancreatic beta cells in Type 1 diabetes.