Project #84 supports Gabriella Cynthia Giese’s research on how yeast cell wall components activate islet macrophages to expand insulin-producing beta cells, exploring ways to prevent or treat type 1 diabetes.
This grant supports research into how pregnancy drives adaptive changes in beta cell metabolism and function, aiming to inform therapies for type 1 diabetes.
This grant supports research into how non-glucose nutrients, especially amino acids, boost human beta cell insulin secretion to advance type 1 diabetes therapies.
Project #86 supports Keiichiro Mine at Boston College in studying whether the gut microbial metabolite isoLCA can reduce inflammatory immune-cell activation to help prevent type 1 diabetes.
This grant supports research on how BNIP3-mediated mitophagy affects beta cell identity and immune response in type 1 diabetes, aiming to uncover new therapeutic approaches.
Project #76 supports Vira Kravets at UC San Diego in studying alpha cell dysfunction and immune targeting as possible triggers of type 1 diabetes, potentially informing prevention and treatment.