Project #87: Leveraging circadian biology to enhance the function and the survival of transplanted human stem cell-derived ß-cells for the treatment of T1D
This grant supports research using circadian biology to improve the function and survival of transplanted stem cell-derived beta cells for type 1 diabetes treatment.
Funder: Diabetes Research Connection
Due Dates (Anticipated): May 2027 (Full application deadline, projected)
Funding Amounts: Up to $75,000 per project; typically for 1 year.
Summary: Supports research leveraging circadian biology to improve function and survival of stem cell-derived beta cells for type 1 diabetes therapy.
Description
This opportunity supports innovative research investigating how circadian biology can be leveraged to enhance the effectiveness and longevity of transplanted human stem cell-derived beta cells for the treatment of type 1 diabetes (T1D). The focus is on understanding and manipulating the cellular circadian clock in beta cells—crucial for regulating insulin release and maintaining steady energy levels. By identifying key genes and proteins involved in circadian regulation, the research aims to optimize the timing mechanisms in stem cell-derived beta cells, enabling improved function and potentially offering a lasting therapeutic solution for T1D.
