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    Real-World Evidence Innovation Challenge

    Real-World Evidence Innovation Challenge supports individuals, teams, and entities validating clinical data analytic methods to establish reliable, reproducible performance across health systems.

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    AI in Healthcare Research Grants
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    This grant was recently updated

    NIH replaced the pending prize announcement with a purse of up to $6 million: up to 12 teams will receive $50,000 each for Phase 1. Phase 2 anticipates up to three $1 million, three $600,000, and six $100,000 prizes, with new workflow execution and performance requirements.

    Advance Whole-Person Data Integration and Reimagine Data Science Computations and Analytics to Address Chronic Disease Disparity Grand Challenge

    Advance Whole-Person Data Integration and Reimagine Data Science Computations and Analytics to Address Chronic Disease Disparity Grand Challenge supports teams building reusable data tools to reduce disease disparities.

    NIH ChallengesDue Nov 23, 2026· 20d$385,000

    Childhood, Adolescent and Young Adult Cancer Data Innovation Challenge

    Childhood, Adolescent and Young Adult Cancer Data Innovation Challenge supports institutional teams building data resources and analytical tools to advance cancer insights and improve young patients' outcomes.

    NIH ChallengesDue Nov 13, 2026· 10d$566,665

    NIDDK Early Research Partnership Engagement Challenge

    NIDDK Early Research Partnership Engagement Challenge supports academic and community partners in early engagement to shape future prevention or treatment research within NIDDK’s mission.

    NIH ChallengesDue Nov 30, 2026$325,000

    Digital Twins and/or Synthetic Data Population Modeling for Whole-Person Health to Mitigate Chronic Disease Disparities Grand Challenge

    NIH Challenges funds digital twin and synthetic data modeling research to advance whole-person health and reduce chronic disease disparities through integrated, AI-ready computational platforms.

    NIH ChallengesDue Feb 19, 2027$440,000

    Repurposing Generic (ReGen) Drugs Evidence Package Challenge

    Repurposing Generic (ReGen) Drugs Evidence Package Challenge supports individuals, teams, and entities reviewing evidence for new generic drug uses to expand affordable treatment for high-cost conditions.

    NIH ChallengesDue Jan 15, 2027$100,000