NIH Challenges
NIH Challenges is an initiative within the National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services, designed to promote innovation and accelerate biomedical research through prize competitions. The program leverages the power of challenges and prize incentives to solve complex health and science problems that traditional funding mechanisms may not address efficiently. NIH Challenges encourages participation from a diverse range of individuals, organizations, and communities, fostering novel approaches to biomedical research, technology development, and health improvement. By offering monetary and recognition-based awards, the initiative aims to stimulate creative solutions that can lead to breakthroughs in disease prevention, diagnosis, treatment, and health equity. This approach complements NIH’s broader mission to seek fundamental knowledge about living systems and apply that knowledge to enhance health, lengthen life, and reduce illness and disability. NIH Challenges operates under the authority of the America COMPETES Act and the Prize Authority, enabling federal agencies to conduct prize competitions to spur innovation. The program's challenges typically focus on areas such as rare diseases, cancer, infectious diseases, data science, and health disparities, among others. NIH Challenges also promotes open collaboration and dissemination of results to maximize the impact of the solutions generated through these competitions.
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29 grants2026 “$100,000 Start an SUD Startup” Challenge
NIH Challenges' 2026 “$100,000 Start an SUD Startup” Challenge supports teams translating research on drug use and SUD into biotech startups through mentorship and cash prizes.
Childhood, Adolescent and Young Adult Cancer Data Innovation Challenge
The NIH Challenges' Childhood, Adolescent and Young Adult Cancer Data Innovation Challenge funds new data tools and methods to advance research and insights in pediatric and AYA cancers.
Advance Whole-Person Data Integration and Reimagine Data Science Computations and Analytics to Address Chronic Disease Disparity Grand Challenge
NIH Challenges' Grand Challenge seeks innovative, AI-ready data integration and analytics solutions to advance whole-person chronic disease disparities research.
26 more grants from NIH Challenges
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